Adult Still’s disease is a condition in which adults present with symptoms similar to those of juvenile arthritis with systemic onset. The cause of adult Still’s disease is not yet clear, and may be related to genetic, infectious and immune abnormalities, etc. Common symptoms include rash, fever, sore throat, muscle and joint symptoms, and in severe cases, multi-system and multi-organ damages may occur, and the diagnosis of this disease needs to gradually exclude other autoimmune diseases, tumors and other diseases before a clear diagnosis can be made. Rheumatoid factor, antinuclear antibody, CRP, blood sedimentation, X-ray and other auxiliary tests can provide clues for the diagnosis of the disease. The treatment of adult Still’s disease is mainly based on drug therapy, and the commonly used drugs include anti-rheumatic drugs such as methotrexate, glucocorticosteroids such as prednisone and non-steroidal anti-inflammatory drugs such as celecoxib, etc. It is recommended to confirm the diagnosis of adult Still’s disease. Patients diagnosed with adult Still’s disease are recommended to go to the rheumatology and immunology department and other related departments of regular hospitals for detailed consultation and treatment as prescribed.