Indacaterol is better than tiotropium bromide. Indacaterol increases pulmonary ventilation better than tiotropium bromide. Indacaterol is a new type of inhaled long-acting β2 agonist, which is lipophilic and can be rapidly absorbed into the systemic circulation, taking effect 5 minutes after the first inhalation on the first day, and it takes only 15 minutes to reach the maximum drug concentration. Tiotropium bromide is a new type of long-acting anticholinergic drug, which can last for more than 15 hours after a single inhalation. In patients with COPD, indacaterol is given to increase lung ventilation better than tiotropium bromide. In clinical practice, the choice of indacaterol or tiotropium bromide should be based on the specific condition and under the guidance of a physician.