Low alpha-fetoprotein is generally physiological factors, if pregnant women with low alpha-fetoprotein may be caused by fetal Down’s syndrome and other reasons, it is recommended that timely medical treatment. 1. physiological factors: low alpha-fetoprotein may be a normal phenomenon, most people usually do not have alpha-fetoprotein in the serum, if there is a low alpha-fetoprotein, there are no uncomfortable symptoms, usually belong to the normal phenomenon, usually do not need special treatment. 2. Fetus with Down’s syndrome: normal pregnant women’s blood alpha-fetoprotein value is 2.5 mom, if the value of alpha-fetoprotein is found to be lower than normal after Down’s screening, that is, lower than the normal value of 2.5 mom, it means that the fetus has the risk of Down’s syndrome, and it is recommended to consult a doctor in time to carry on the amniocentesis or non-invasive prenatal DNA test, if confirmed, it is recommended to terminate the pregnancy in time. It is recommended to seek timely medical treatment for relevant examinations and, depending on the specific situation, under the guidance of the doctor.