Insomnia is a common neurological symptom in maintenance hemodialysis patients, and treatment includes general and pharmacologic therapy. Insomnia in dialysis patients may be manifested as difficulty in falling asleep or waking up easily at night, which may be related to excessive daytime dialysis sleep and restless leg syndrome. Among them, restless legs syndrome is characterized by abnormal sensation deep in the muscles, burning sensation, accompanied by severe pain, etc., and the pain is so severe that it seriously affects sleeping. 1. General treatment: quit smoking and drinking, appropriate exercise, eliminate tension, massage or hot bath can reduce symptoms. 2. Drugs: including clonazepam, eszopiclone and so on. It should be noted that the drugs have dependence, but also dry mouth, drowsiness, dizziness, fatigue and other discomforts, prohibited in myasthenia gravis, glaucoma, severe chronic obstructive pulmonary disease. Dialysis patients with insomnia, it is recommended to consult the doctor in the dialysis center, under the guidance of the doctor’s treatment, the drug should be used in accordance with the doctor’s instructions, do not self-medication.