Lung cancer is a common malignant tumor of the respiratory system, and lung cancer can reach the bone through blood line metastasis, clinically, comprehensive treatment measures should be taken for the pain caused by bone metastasis of lung cancer.1. Chemotherapy and targeted therapy should be used appropriately to control the lung cancer, so that the pain caused by bone metastasis can be alleviated while treating the primary disease.2. Suitable analgesic drugs should be selected according to the degree of pain.3. Zoledronic acid, desutumumab and other drugs can not only relieve the pain of patients, but also stabilize the bone metastases.4. The application of zoledronic acid, desutumumab and other drugs can not only relieve the pain of patients, but also stabilize the bone metastases.4. The use of radiation therapy to treat bone metastases can not only control the lesions, but also achieve the effect of analgesia. After reasonable comprehensive treatment measures, most patients’ pain can be effectively relieved and their quality of life can be improved.