The commonly used therapeutic drugs for TB Hirschsprung’s reaction are glucocorticoid drugs such as prednisone, in addition to symptomatic treatment such as combined fluid withdrawal. Hirschsprung’s reaction of tuberculosis refers to the phenomenon of temporary deterioration of tuberculosis in the course of chemotherapy for tuberculosis, which is mainly manifested by the appearance of new foci on the X-ray, which can be manifested as the expansion of the scope of the original foci, and foci that were not present or undetected before the deterioration are detected after the deterioration of the reaction. Tuberculosis-like Hirschsprung’s reaction drug treatment is mainly the application of glucocorticosteroids, commonly used including prednisone and so on. At the same time, continue their original anti-tuberculosis drug therapy, such as isoniazid, ethambutol and so on. In addition, Hirschsprung’s reaction is prone to pleural effusion and other symptoms, and requires timely fluid extraction and other symptomatic treatment. Hirschsprung’s reaction in tuberculosis treatment is most common in the following situations: intensive chemotherapy for first-treatment cases; sputum-positive cases; hematogenous and severe tuberculosis, and so on. If there is any discomfort, it is recommended to seek prompt medical attention for diagnosis and treatment. The use of drugs should be under professional guidance.