If there are malignant tumors in the body, such as pancreatic cancer, gallbladder cancer, bile duct cancer, colorectal cancer, etc., if CA199 is significantly higher than normal, to lower CA199 definitely requires anti-tumor treatment, such as surgery, chemotherapy, radiotherapy, targeted drug therapy, etc. Only when the tumor in the body is under control, CA199 will have Only when the tumor in the body is under control, CA199 may drop. If there is acute pancreatitis, cholestatic cholangitis, cirrhosis, etc. in the body, the serum CA199 may also be elevated to different degrees. Sometimes only a mild elevation of CA199 is found during physical examination, and the absence of any disease in the body can be treated without treatment, as long as the changes in CA199 are regularly observed.