Prevention of recurrence after rectal cancer surgery should be based on active comprehensive treatment, regular review and follow-up, reasonable diet and healthy living habits, etc. The premise needs radical surgery to be thorough. The 5-year survival rate of early-stage rectal cancer after surgery can reach 90%, and the risk of recurrence is about 1.2%-4.9%; for locally advanced rectal cancer, after surgery, radiotherapy, chemotherapy and other comprehensive treatments, the 5-year survival rate is about 50%-78%; the prevention of recurrence needs to pay attention to the following points: 1. First of all, radical surgery for rectal cancer must be thorough, not only the tumor should be completely resected, but also the surrounding lymph nodes should be thoroughly cleared. 2. Postoperative comprehensive treatment is an important link, including chemotherapy with 5-fluorouracil + LV regimen, intraperitoneal chemotherapy, lymphatic targeted chemotherapy and chemotherapy for its metastatic foci, radiotherapy, biological therapy, traditional Chinese medicine therapy, etc. 3. Regular review and follow-up, such as CEA, AFP, CA199, CA125 and other indicators, CT, PETCT and other imaging tests, colonoscopy, etc.; pay attention to follow-up consultation. 4. Reasonable diet and healthy living habits: diversify dietary structure, develop good habits, eat more fresh vegetables and fruits, do not eat polluted food; keep bowel movement smooth; relax mood, combine work and rest, and live a regular life; exercise reasonably to enhance physical fitness. Adverse symptoms after rectal cancer surgery need to seek medical treatment in time and as early as possible to prolong the survival period as much as possible.