Patients with angina pectoris can be treated with anticoagulation therapy to prevent thrombus formation during acute attacks of angina pectoris with subcutaneous injections of low molecular heparin sodium or low molecular heparin calcium. Long-term anticoagulation therapy for patients with angina can be performed with anti-platelet aggregation drugs such as aspirin, clopidogrel, and tigretol. If the patient has gastrointestinal bleeding, it is best not to use aspirin, which increases the risk of gastrointestinal bleeding. Patients with angina pectoris who have a combination of atrial fibrillation and a CHADS score of 2 or more can be treated with anticoagulation with warfarin or rivaroxaban. In addition to anticoagulation, patients with angina pectoris should be treated with lipid-lowering drugs to stabilize plaque and drugs to reduce myocardial oxygen consumption.