Aspirin should be taken only after 12 hours of drinking because alcohol is a substance that has a blood-activating effect and it contains ethanol, which usually has some effect with the epoxide dismutase in aspirin. If a large amount of alcohol is consumed followed by oral aspirin, platelet inhibition will be evident and there will be a significant tendency to bleed. If excessive alcohol consumption leads to nausea, vomiting, or even violent vomiting, this usually results in erosion and reflux of the gastric mucosa, or in more severe cases, vomiting of blood. If you take aspirin at this time, there will be obvious symptoms of upper gastrointestinal hemorrhage and even trigger hemorrhagic shock, so you should only take aspirin 12 hours after drinking. If you experience severe nausea, vomiting, or even vomiting blood after drinking, you should not take aspirin for 3 days.