High alkaline phosphatase is relatively serious and common. Normal reference values for alkaline phosphatase range from 45 to 125 U/L in males, 30 to 100 U/L in females between the ages of 20 and 49, and 50 to 135 U/L between the ages of 50 and 79. Generally, elevated alkaline phosphatase is more common in the clinic, and it is also mildly elevated in diseases of the hepatobiliary system, such as intra- and extra-hepatic bile duct obstructive diseases; bone diseases, such as fibrous osteitis, rickets, osteoblastoma; and malnutrition, severe anemia, and other diseases. Low alkaline phosphatase is mainly seen in cretinism, vitamin C deficiency, hypophosphatasia, etc. Low alkaline phosphatase levels are relatively rare and less severe than high alkaline phosphatase levels. It is recommended to consult a doctor for standardized diagnosis and treatment when necessary.