Shoulder pain, the whole body often itchy and painful may be related to the nerve, such as autonomic nerve disorders, neurodermatitis and other diseases, may also be psoriasis, urticaria and other diseases. 1. Autonomic nerve disorder: this disease is mainly caused by long-term mental tension, excessive psychological pressure and other factors, common causes also include genetics, trauma, nutrition and metabolism. Because the patient will have generalized wandering pain and abnormal infection, it can be manifested as shoulder pain in some cases, and the whole body is often itchy and painful. 2. Neurodermatitis: the cause of the disease is not clear, studies show that with poor sleep, fatigue, overthinking and other neurological factors, followed by endocrine disorders, improper diet, clothing materials and other reasons. Skin lesions often occur in the shoulder, neck, back and other parts of the body, local itching, pain and other symptoms, so some patients have shoulder pain, the whole body often itchy and painful. 3. Psoriasis: clinically, it is believed that the occurrence of this disease is the result of the combined effect of genetic and environmental factors, including excessive stress, obesity, pathogenic microbial infections, skin injuries and so on. Common symptoms include itching, pain or burning sensation of the skin. Therefore, patients may have shoulder pain and frequent itching and pain all over the body. 4. Urticaria: The cause of urticaria is more recurrent and may be related to various factors such as animal proteins, pathogenic microbial infections, pressure friction, and sunlight exposure. If it is pressure urticaria, when the skin is stimulated by pressure, then itchy, burning or painful edema-like plaques, mostly manifested as shoulder pain, the whole body often itchy, and some patients will also appear cold. It is recommended that patients with shoulder pain and generalized itching go to the hospital in time and cooperate with the doctor to actively treat the primary disease.