In clinical practice, there is no single signal that can confirm the diagnosis of lymphoma. Instead, lymphoma patients may have symptoms such as swelling of surface lymph nodes, systemic symptoms, extra-nodal organ involvement, etc. The final diagnosis depends on pathologic biopsy. 1. Enlargement of surface lymph nodes: the first symptom of most lymphoma patients is painless progressive lymph node enlargement, which can be detected on the surface of the body, and the common areas are neck, supraclavicular region, axilla, groin, etc. The enlarged lymph nodes can be pushed up and down. The enlarged lymph nodes can be pushed, or they can adhere to each other and fuse to form a mass. Hodgkin’s lymphoma patients may also have lymph node pain after drinking alcohol. 2. Systemic symptoms: patients with lymphoma may have some systemic symptoms, such as low-grade fever, night sweating, itching, emaciation and so on. Some patients will start with persistent fever of unknown cause. 3. Extra-nodal organ involvement: theoretically, lymphoma can occur in lymph nodes and lymphatic tissues all over the body, and lymphoma located in organs or tissues will cause corresponding manifestations, for example, patients with pulmonary lymphoma can have cough, sputum, hemoptysis, dyspnea; patients with pharyngeal lymphoma can have nasal congestion, nosebleed, dysphagia and so on; gastrointestinal lymphoma can cause abdominal pain, diarrhea, abdominal mass and so on. 4. Pathological examination: if the patient has typical progressive and painless lymph node enlargement, lymph node prints, pathological section or lymph node puncture smear examination can be done to make a clear diagnosis. Skin biopsy can be done if skin lesions are present. Bone marrow biopsy and smear may be performed to confirm the diagnosis if accompanied by abnormal blood cell counts, elevated serum alkaline phosphatase, or localized bone lesions. Patients who are suspected of having lymphoma are recommended to go to the hospital as soon as possible for consultation, so that they can be diagnosed as soon as possible and treated accordingly.