Itchy hands in the middle of the night is first considered to be caused by allergies, such as prolonged use of alkaline laundry soap, or contact with sensitive items. It is recommended to avoid contact with allergens, pay more attention to diet, and eat more light foods. Secondly, itchy hands in the middle of the night is considered to be a reaction to chronic inflammation, and symptomatic anti-inflammatory treatment is recommended. In addition, itchy hands in the middle of the night is also related to the lack of B vitamins, it is recommended to eat more food rich in B vitamins to ensure balanced nutrition, which is conducive to faster relief of symptoms.