There are several possibilities for itching on the body in the middle of the night: 1, it may be pruritus, mainly due to suffering from a variety of internal diseases, or the skin is too dry and other reasons, can be treated with oral dicloretin dry suspension, and topical application of glyburide lotion. 2, scabies caused by scabies infection, the appearance of tiny papules between the fingers, around the umbilicus and scabies burrowing tunnels, in the buttocks and vulva appear large nodules. You can apply Clomid ointment, or sulfur ointment for treatment, and large nodules can be treated with topical Denide ointment. 3, urticaria, which may be caused by infection or allergy, or by internal diseases such as thyroid, can be treated clinically by taking Avastin capsules orally 3 times a day, 1 capsule once, and taking 1 capsule at night for 1 day in combination with loratadine citrate.