Menopausal patients can reasonably apply estradiol gel under the guidance of the doctor, but long-term use is not recommended. Patients should follow the doctor’s instructions to grasp the appropriate dosage. If abnormal symptoms occur during the use of estradiol gel, it is necessary to stop the medication and consult a doctor. Estradiol Gel is mainly used to treat patients with estrogen deficiency to improve the symptoms of flushing, profuse sweating, insomnia, vaginal dryness and other discomforts caused by estrogen deficiency. Due to the lack of estrogen in menopausal women, estradiol gel can be applied as prescribed by the doctor, but it is not recommended to apply it for a long time, otherwise it may induce endometrial cancer. After using estradiol gel, if the clinical symptoms improve, it is recommended to ask the doctor whether to stop using the drug. Estradiol Gel should not be used if menopausal women have symptoms of irregular vaginal bleeding or active thrombophlebitis. If after applying estradiol gel, patients experience adverse reactions such as dizziness, headache, nausea, etc., they need to stop using the drug and go to the hospital for medical consultation.