The main difference between orlistat 60 mg and 120 mg is in the dosage, but its active ingredients, drug effects, adverse reactions, etc. are the same, it is recommended to follow the doctor’s instructions. Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor, which inhibits lipase activity and reduces the digestion and absorption of fat from food, and is used in the treatment of obese or overweight patients (body mass index ≥ 24). The drug exists in 60 mg and 120 mg sizes, with 120 mg available for those with a large weight base and a fatty diet, and 60 mg for those with a smaller base and a lighter diet. Orlistat is suitable for obese and overweight people, common adverse reactions include increased gastrointestinal gas, increased stool frequency, steatorrhea, fecal incontinence, etc. Contraindications include minors, pregnant women and lactating mothers, people who are allergic to the drug, patients with chronic malabsorption syndrome and cholestasis, patients with organic obesity, organ transplant recipients and people taking cyclosporine, and people who are not overweight. Orlistat belongs to the category of non-prescription drugs, it is recommended to use the drug under the guidance of a doctor.