Nowadays, many people have heard of osteomyelitis, and there are often advertisements posted inside some alleys specializing in osteomyelitis, which means that there must be many patients suffering from osteomyelitis. So, what exactly is osteomyelitis? What does it have to do with diabetic foot? Osteomyelitis is usually described as inflammation, infection and destruction of bone and bone marrow, with infection being one of its main causes, as well as osteomyelitis caused by hematogenous and open fractures. Nowadays, osteomyelitis and diabetic foot are often inseparable, and one of the typical complications of diabetic foot is causing osteomyelitis. It has been reported that 15% of patients who develop diabetic foot ulcers develop osteomyelitis, while 20% of patients who develop diabetic foot infections develop osteomyelitis. According to the current situation, it is common for diabetic foot patients that osteomyelitis is often overlooked, and clinical diagnosis is difficult, with a greater chance of omission and misdiagnosis in general practice, leading to aggravation of osteomyelitis without effective control. At present, regarding the treatment, the first step is definitely to make a clear diagnosis. The method can be based on the location, size, edges, base, adjacent tissues, secretions, etc. of the wound, but also in combination with the patient’s vascular lesions, neuropathy and immune diseases for evaluation. Medical examinations are also indispensable, dealing with blood tests regarding infection, but also in combination with imaging see sweat, such as X-rays, CT, ultrasound, bone imaging, bone aspiration biopsy and other examinations. With regard to treatment, osteomyelitis is currently a worldwide problem, and overall amputation is very high. In general, the risk of amputation caused by acute diabetic infection with osteomyelitis is four times higher than that caused by acute diabetic infection with soft tissue infection. Moreover, once osteomyelitis develops, it requires more time for antimicrobial drug treatment, which will undoubtedly increase the financial burden on patients and their families. The ultimate goal of osteomyelitis treatment is to achieve limb preservation whenever possible, which is not a dream but an achievable fact. The diabetic foot and osteomyelitis can be healed through a combination of Chinese and Western medicine open therapy, through the comprehensive treatment of debridement, infection control, improving circulation, nutrition of the trauma and elimination of decay and muscle, etc. I hope that you will encounter this situation must be more understanding and more consultation, to avoid blind treatment to the patient’s body and mind caused irreversible damage.