Whether patients with nephrotic syndrome can eat cefixime should be based on the patient’s renal function to decide, renal function is good or slight abnormalities can eat cefixime, severe renal insufficiency patients should be cautious with cefixime. Cefixime belongs to the third generation of cephalosporin antibiotics, broad antibacterial spectrum, antibacterial activity against some gram-positive and negative bacteria, mainly excreted through the kidneys, in patients with nephrotic syndrome in vivo half-life may be prolonged, and therefore should be according to the renal function status of the appropriate amount of reduced dose, the dosage interval should be appropriately increased. Cefixime should be administered with caution in patients with severe renal dysfunction. Cefixime may cause stomach upset in some patients, and is contraindicated in those who are allergic to the product. When patients with nephrotic syndrome need to use antibiotic treatment, they should go to the hospital in time to ask the professional physician, and standardize the use of drugs under the guidance of professional doctors to avoid adverse drug reactions.