Frequent coughing at night needs to be treated according to different diseases of the respiratory system, circulatory system and digestive system, such as bronchodilating or anti-infection, improving circulation and acid suppression. 1. Respiratory system, common cough variant asthma, pneumonia, etc., can cause night cough, especially cough variant asthma with typical symptoms of nocturnal paroxysmal cough, can be targeted to use salbutamol and other bronchodilating treatment for pneumonia, should be combined with the aetiology of the application of anti-infective drugs, such as ceftriaxone, levofloxacin and so on. 2. Circulatory system, mainly refers to cardiac insufficiency, which can affect the local circulation of the heart and cause cough. Generally use digitalis, torasemide, etc. to improve circulation treatment. 3. Digestive system, gastroesophageal reflux is a common cause of nocturnal cough, which needs to be treated with acid-suppressing drugs such as omeprazole. The specific cause of the cough needs to be clarified after medical examination, and the treatment should be carried out according to the doctor’s instructions.