The upper limit of normal aminotransferase value is 40 U/L, so when the aminotransferase value reaches 8000 U/L, it is already 200 times above the normal value, suggesting that there may be significant and extensive hepatocellular necrosis. Although hepatocytes are highly regenerative and capable of repair, if the extent of necrosis exceeds the compensatory capacity of the liver, this can lead to acute liver failure or fulminant liver failure. Patients will not only develop serious complications such as upper gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome and intractable ascites, but also may develop multi-organ failure such as renal failure and respiratory failure within a short period of time, which eventually leads to the death of the patient. These diseases not only progress rapidly and are poorly treated, but also have a high mortality rate, and sometimes the only way to save lives may be through artificial liver or eventual liver transplantation.