Severe leg pain due to rheumatism in the elderly is most often seen in osteoarthritis. The main treatment includes the application of anti-inflammatory drugs and hormonal drugs and anti-rheumatic drugs. Application of non-steroidal anti-inflammatory drugs can play the role of antipyretic, analgesic and anti-inflammatory effects, which can relieve pain faster and have better analgesic effects. Commonly used drugs include aspirin, ibuprofen, etc. The elderly should be used with caution, and patients with a history of peptic ulcers should be more cautious. Hormonal drugs are often glucocorticoids, such as cortisone, prednisone, etc. They have powerful anti-inflammatory and immunosuppressive effects and can effectively relieve symptoms, but there are many adverse effects of long-term use in large quantities, including infections, hyperglycemia, hypertension, and so on. Anti-rheumatic drugs can improve the condition and slow down the progress of the disease, commonly used drugs include LiuZhouShengXinDi, methotrexate, etc., but the effect is slower, mostly used for long-term maintenance treatment after remission, and should not be used for acute pain episodes. All of the above drugs should be used under the guidance of a physician, do not take medication on your own, in order to avoid adverse consequences.