Tonsillar suppuration often refers to acute suppurative tonsillitis, which is mainly caused by type B hemolytic streptococcal infection and occurs more often when the patient’s resistance is lowered. Typical clinical manifestations are severe sore throat, pain aggravated by swallowing, and some patients may have systemic symptoms such as chills and fever. The application of antibiotics is the main treatment method, and cephalosporin and amoxicillin are both commonly used in the treatment. Penicillin antibiotics are preferred in the treatment of this disease, i.e., amoxicillin, meloxicillin, etc. The route of administration is decided according to the severity of the disease; if the disease does not improve and the high fever does not subside after 2~3 days of treatment, other kinds of antibiotics, including cephalosporin, may be switched to after analyzing the cause. Amoxicillin and cephalosporins are prohibited in patients who are allergic to penicillin, and macrolides can be chosen. If the diagnosis of purulent tonsillitis is confirmed, standardized medication and treatment should be guided by the physician after clarifying the cause of the disease.