The main symptoms of chronic hepatitis B are as follows: 1, systemic manifestations: fatigue, easy fatigue, mild fever, insomnia, etc.; 2, digestive tract: loss of appetite, nausea, anorexia, abdominal distension, etc.; 3, jaundice: bilirubin uptake combined with secretion and excretion disorders, so that the concentration of bilirubin in the blood rises, and yellow urine, skin and sclera yellowing; some of which may appear itchy skin; 4, hepatic pain: vague pain in right upper abdomen or right quaternary rib area, pressure pain or percussion pain in the liver area, to avoid misdiagnosis. Hidden pain in the right upper abdomen or right quarter rib area, pressure pain or percussion pain in the liver area; if there is severe pain in the liver area, attention should be paid to differentiate it from biliary tract diseases, hepatocellular carcinoma and gastrointestinal diseases to avoid misdiagnosis; 5. Hepatomegaly: caused by inflammation of the liver, congestion, edema and biliary stasis; in the advanced stage, a large number of hepatocytes are destroyed, hepatic fibrotic tissues are contracted, and the liver can be reduced in size; 6. Extra-hepatic manifestations: there is darkness of the complexion (the face of liver disease), hepatic palms and Spider nevus (mainly face, neck, forehead, back, upper limbs, etc., abdomen and lower limbs do not appear; sexual dysfunction in men, menstrual disorders, amenorrhea, loss of libido in women, etc.); 7. Liver fibrosis: further development, early cirrhosis.