Once a patient enters the advanced stage of uremia, the patient has very many symptoms, but the clinical symptoms are not always exactly the same from patient to patient. Usually the most important symptoms of patients are nausea, vomiting, not wanting to eat, decreased appetite, and even abdominal distention, increased stool frequency, and gastrointestinal bleeding. Patients may also experience dizziness, headache, significantly higher blood pressure, and even panic, chest tightness, and shortness of breath. Pallor, anemia, itchy skin, joint pain, and muscle weakness may also occur in the late stage of uremia. In terms of the nervous system, patients with advanced uremia show insomnia, and may even experience impaired consciousness, unresponsiveness, babbling, and also convulsions and coma. Patients may also show reduced urine output and edema, especially edema of the face and both lower limbs is very obvious. In conclusion, there are many symptoms of late stage uremia, and once you have the above symptoms, you need to seek medical attention for appropriate treatment.