The time it takes for diabetic nephropathy to progress to uremia is often very much related to the control of the patient’s basal blood sugar and the importance the patient attaches to it. If patients can usually manage their blood sugar well, other risk factors, such as blood pressure, lipids, uric acid, if controlled to standard, patients tend to progress slowly, and may not be in 20-40 years will certainly occur in end-stage renal disease. That is, if the diabetic nephropathy stage III, very active intervention, which can greatly delay the progression of the disease, the patient’s diabetic nephropathy, will not progress to uremia in a short period of time. When diabetes progresses to uremia, it should belong to stage V, also called end-stage nephropathy, which often occurs 20-40 years after the onset of diabetes, accompanied by a continuous decrease in glomerular filtration rate and an increase in blood pressure, within 10-18 years, 50%-75% of patients will enter end-stage nephropathy. After entering this period, patients often need dialysis and other treatments, and a variety of complications will gradually appear during this period. For example, renal bone disease caused by nephropathy, if further progress, often also heart failure, uremia, etc..