The pathogenesis of diabetic nephropathy is mainly manifested in the following four aspects: 1, genetic susceptibility genes and factors of type 1 diabetes and type 2 diabetic nephropathy; 2, glomerular arteriosclerosis has a relationship with the dynamic relationship of blood flow, closely related to the expansion of the glomerular entry artery, so that the glomerular pressure is elevated; 3, urinary protein excretion rate, excretion, is a good indicator to determine the condition of diabetic nephropathy, and is one of the causative factors of diabetic nephropathy; 4. Glucose has a toxic effect on tissues, and the toxicity of glucose as a study, deep into the molecular level, for example, it has been shown that diabetic glucose, especially in a high concentration state, can activate proteinase C, the end product of glycated protein, which can lead to damage the structure and function of cells. The clinical manifestations and hazards of diabetic nephropathy have long been known, but the pathogenesis has not been fully elucidated until now. In the last 20-30 years, there has been a relatively large progress in the study of the mechanisms of the occurrence of diabetes. It is certain that there are many factors in the etiology and pathogenesis of diabetic nephropathy, some are independent factors, some are not, and there are often synergistic or interactive effects between various factors.