Nucleic acid testing usually refers to the novel coronavirus nucleic acid test, and going for a nucleic acid test during a cold usually does not interfere with the results of the nucleic acid test. The novel coronavirus nucleic acid test detects the presence of the genes of the novel coronavirus in a sample of exfoliated cellular tissue scraped from the nose, throat, or anus to confirm the presence of the novel coronavirus infection. Colds are mainly caused by bacterial or viral infections, of which viruses include rhinovirus, parainfluenza virus, respiratory syncytial virus, coxsackievirus and echovirus. It can be seen that colds do not interfere with the results of nucleic acid tests. Furthermore, nucleic acid tests are characterized by high specificity and sensitivity, and usually do not lose their accuracy due to colds. In addition, patients must wear a mask throughout the nucleic acid test and keep a safe distance of more than one meter from people around them to reduce the possibility of cross-infection, and if the test results are positive, they should be isolated and treated in a timely manner.