Hepatitis B 1245 positive is not more difficult to treat. Hepatitis B 1245 positive usually means that the patient is in a period of immune instability, the body’s immunity may be activated and is fighting against the hepatitis B virus, the surface antigen of hepatitis B may be disappearing gradually, and the body is transforming to a clinical recovery, which is currently in the recovery period of hepatitis B. If the transaminase is not abnormal, clinical treatment is generally not necessary and follow-up observation is sufficient. In some patients, the virus may become active again and may change to 145 positive. Clinically, it is generally necessary to carry out quantitative testing of hepatitis B virus DNA and liver function test, according to the level of virus and whether the transaminase is abnormal, etc., under the guidance of the doctor to determine whether it is necessary to carry out regular antiviral treatment. Commonly used drugs are entecavir, tenofovir and so on.