Methods to get rid of melasma include topical medication, systemic medication and phototherapy. 1. Topical drug treatment: decolorizing agents such as 2%~5% hydroquinone cream, 15%-20% azelaic acid cream, 4% tretinoin or compound arbutin cream. These drugs can inhibit the activity of tyrosinase, thus effectively reducing the production of pigment. In addition, superoxide dismutase, or SOD, can reduce melanin production by scavenging as well as inhibiting oxygen free radicals. Concentrations of 0.025% to 0.1% retinoic acid can also affect melanin metabolism to some extent. In addition, decolorizing agents can also have better therapeutic effect if they are combined with the chemical peeling effect of fruit acids. 2. Systemic medication: for example, oral tranexamic acid, vitamin E and vitamin C. 3. Photoelectricity treatment: Picosecond laser and other photoelectricity treatments are effective for chloasma, but we should pay attention to the adverse reactions. Melasma patients should go to regular medical institutions for consultation and use medication under the guidance of physicians.