There is no obvious direct relationship between knee pain and the progression of femoral head necrosis. To determine the progression of necrosis of the femoral head, it is necessary to combine the symptoms of necrosis of the femoral head, clinical examination and other comprehensive judgment, and exclude other diseases. Necrosis of the femoral head is caused by the interruption or damage of the blood supply to the femoral head, resulting in damage to the bone cells and bone marrow components, which leads to the collapse of the femoral head and structural changes, causing joint pain and joint dysfunction. Early manifestations of necrosis of the femoral head are mostly joint pain in the groin, buttocks and thighs, and occasionally knee joint pain. The pain is intermittent and gradually aggravated, if bilateral necrosis of the femoral head can appear alternating pain. To determine the progress of femoral head necrosis, it is necessary to combine with X-ray radiographs of the femoral head and other related examinations. Knee ligament injury, meniscus injury, osteoarthritis and so on may cause knee pain. To determine whether the knee pain is related to the femoral head necrosis condition needs to be considered to exclude these disease factors. It is recommended that patients with osteonecrosis of the femoral head actively seek medical treatment when knee pain occurs.