Clinical manifestations of uremia include heavy urination (24-hour urine output can often exceed 4L in patients with uremia), extreme thirst with heavy drinking, low specific gravity urine that is the color of water, and often accompanied by irritability. Children with uremia are often characterized by unexplained crying, frequent need for water at night, poor sleep quality, and slow weight gain. There is individual variability in the clinical manifestations of patients with uremia. Uremia is an endocrine disorder primarily associated with arginine pressin. As hypotonic polyuria can cause excitation of the hypothalamic thirst center, it will cause patients to be irritable and extremely thirsty, followed by drinking a lot of water. Children with urosepsis behave similarly to adults, and if water is forcibly prohibited, it can cause dehydration, vomiting, irritability, emotional instability and growth retardation, and even coma and death, which needs to be taken seriously by parents. If drinking water is sufficient, the child may have no obvious signs. Patients with urosepsis should be seen under medical supervision to avoid delays.