Calf weltbone, generally refers to the tibia, tibia pain when running, can consider the cause of excessive exercise, osteoporosis, joint wear and tear, tibial tuberosity inflammation, and so on. 1. Excessive exercise: When the amount of exercise is too large and the activity is too strenuous, the compression force on the tibia is excessive, which leads to pain. 2. Osteoporosis: especially osteoporosis caused by lack of calcium, when over-exercise, due to the decline in tibia strength, it is easy to irritate the periosteum and muscle tissues, which may cause bone pain, and may lead to fracture in severe cases. 3. Wear and tear of joints: excessive long-term exercise and incorrect exercise methods can cause wear and tear of the knee joints, leading to osteoarthritis and pain in the calf when running. 4. Inflammation of the tibial tuberosity: When exercising, the tibial tuberosity will be pulled, and when exercising too much, the tibial tuberosity will be pulled excessively and cause inflammatory changes, which may also cause pain. There are many reasons that can cause tibial pain during running, including tibial bone tumor, tibial fracture and tibial osteomyelitis, etc. If the pain continues to be unrelieved or aggravated, you should consult a doctor in time to clarify the cause of the disease and receive appropriate treatment.