Abnormalities in the shoulder and liver cancer may be causally related. Bone metastases from liver cancer can cause pain, numbness, dysfunction, pathologic fracture and other discomforts in the shoulder. It may also have no relationship and be caused by other diseases such as cervical spondylosis and frozen shoulder. Hepatocellular carcinoma is a malignant tumor occurring in hepatocytes or epithelial cells of intrahepatic bile ducts, which often has no obvious symptoms in the early stage, but in the late stage, it may have symptoms such as epigastric pain, jaundice, fever and so on. Bone metastasis may occur in advanced liver cancer and reach the shoulder, which may cause pain, numbness, dysfunction, pathological fracture and other discomforts of the shoulder. Liver cancer may also metastasize to lungs, pleura and other parts, causing symptoms in corresponding parts. Bone metastasis of liver cancer often has poor prognosis, so it is important to consult doctor at the first time when liver cancer is found to avoid metastasis of liver cancer. Besides, other diseases may also cause shoulder discomfort, such as cervical spondylosis and frozen shoulder. It is recommended to consult the doctor as soon as possible if you have any liver disease or shoulder pain, and complete the relevant examination to make a clear diagnosis, so as to avoid delaying the condition.