Rheumatism belongs to the Western class of connective tissue diseases, and a common complication is anemia. The cause of anemia is that connective tissue diseases affect diet and hematopoietic function of the body, resulting in a decrease in hemoglobin, leading to mild, moderate or severe anemia, and treatment such as long-term, intermittent folic acid supplementation to improve anemia. However, the specific medication should be combined with clinical and guided by the doctor’s interview. In addition, treatment is needed for the primary disease. As long as the primary disease is controlled, the symptoms of anemia will be improved naturally.