Progesterone is not recommended when the patient has the following conditions, as follows: 1. Patients with severe hypertensive disease, serious impairment of liver and kidney function, and patients with thrombotic disease must be given reasonable progesterone supplementation under the guidance of a doctor, and the doctor must be informed of the presence of the above-mentioned related diseases for better and more meaningful treatment; 2. A few patients cannot be given progesterone supplementation, such as patients Patients who have been judged by doctors to be at risk of ectopic pregnancy or patients with a high risk of ectopic pregnancy; 3. Forced fetal preservation is not recommended for patients with fetal arrest; 4. Some fetuses identified with congenital abnormal development will not be forcibly preserved; 5. Patients with meningioma cannot use progesterone for fetal preservation; 6. Patients who are allergic to progesterone or whose disease will be aggravated by using progesterone should use progesterone with caution.