The manifestation of pain when the patient presses the upper eyelid on the eyeball may be caused by ocular trauma, blepharitis, glaucoma and other factors. 1. Ocular trauma: Ocular trauma can lead to damage to the eyeball, and patients may experience blurred vision, eyeball pressure and pain, eye swelling and other clinical symptoms. 2. Blepharitis: Blepharitis, also known as granuloma, is an acute, suppurative inflammatory disease caused by staphylococcus and other bacterial infections, and the patient’s eyelids may show redness, swelling, heat and pain, and other clinical symptoms, and if the pustule grows in the upper eyelid, the patient may have a painful sensation of pressure on the eyeball. 3. Glaucoma: Due to elevated intraocular pressure in patients with glaucoma, patients may experience symptoms such as eye distension and pain, photophobia, tearing, etc. Patients may also experience symptoms such as pain when pressing on the eyeball with the upper eyelid. It is recommended that patients with painful pressure on the eyeball should consult a doctor in time to assess their condition and follow the doctor’s instructions for treatment.