Metastasis of esophageal cancer will produce two different types of clinical symptoms: 1. clinical symptoms of compression by tumor metastases; 2. organ dysfunction produced by metastasis to a certain organ. If the disease cannot be effectively controlled, it will eventually lead to organ failure. The most common esophageal cancer metastasis is mediastinal lymph node metastasis, in which enlarged lymph nodes compress the recurrent laryngeal nerve, which will cause hoarseness, choking and coughing when drinking water, and compression of the trachea will cause coughing, coughing up blood, dyspnea and other symptoms. Secondly, blood line metastasis, cancer cells can be transferred to any organ with blood, commonly to lungs, liver and bones. For example, metastasis to lungs can cause corresponding respiratory symptoms, such as coughing, coughing up blood, dyspnea, and even bloody pleural fluid and so on. Metastasis to liver can cause pain in liver area, abnormal liver function and indigestion and some digestive system symptoms. In conclusion, metastasis of advanced esophageal cancer will produce different symptoms in different parts of the body, therefore, early detection, early diagnosis and early treatment are especially important for any cancer.