There are many causes of blisters on the feet, including fungal infections, eczema, localized friction and other causes, which can be dealt with through medication and daily interventions. 1. Fungal infection: Tinea pedis caused by fungal infection may lead to blisters, often accompanied by itching symptoms. Topical antifungal medications such as miconazole ointment and ketoconazole cream can be used topically to intervene. 2. Eczema: foot eczema may lead to localized blisters, which can be treated with topical mometasone furoate gel, halometasone ointment and other medications, and when itching is significant, it can be treated with anti-allergy medications such as oral loratadine. 3. Local friction: these blisters are mainly concentrated in the bony structure or the main stress area, usually a single blister or blood blister, can be intervened by changing comfortable shoes and socks and other measures, usually can be relieved by themselves. Care should be taken to avoid breaking the blisters on their own to avoid inducing infection. For those who have already broken the blisters, anti-infective treatment can be provided with iodophor and erythromycin ointment. It should be noted that the above drugs should be used under the guidance of clinicians, and unauthorized use of medication is prohibited; the emergence of localized blisters is recommended to go to the hospital in a timely manner.