Calluses are medically referred to as calluses, and treatment is usually not required when calluses are present on the hands. If the patient feels that it affects the aesthetic appearance, or there are painful symptoms, it can be treated by general treatment, medication and other ways of treatment. 1. General treatment: remove the causative factors, try to avoid local friction and extrusion. Generally with the reduction of friction and pressure, the lesions can gradually subside. If necessary, hot water can be used to soak, and then use a knife to cut off the thick keratin. 2. Medication: follow the doctor’s instructions to use external exfoliators such as salicylic acid ointment, retinoic acid ointment, etc. to exfoliate the keratin and remove the callus. In daily life, patients should avoid abrasion of the diseased area, and wear gloves to reduce abrasion if necessary.