Calluses on the soles of the feet are called calluses, which can be removed by blades, medicines, physical methods and so on. 1. Razor blade removal: use hot water to soak the soles of the feet, when the callus is softened, use a sterile razor blade to cut off the surface of the stratum corneum. 2. Drugs: Topical exfoliators such as salicylic acid ointment and retinoic acid ointment can be used to promote the exfoliation of the stratum corneum. 3. Physical methods: mainly refers to liquid nitrogen freezing and carbon dioxide laser to eliminate callus, but not commonly used, according to the patient’s specific situation to choose. Specifically under the guidance of a professional doctor, combined with the personal situation of targeted treatment, medication should be used in accordance with medical advice.