Vitamin A cream to get rid of melasma is easy to rebound, and the efficacy is not good. Retinoic acid cream is a kind of epidermal exfoliant, which can affect the metabolism of epidermis and make the epidermal pigment exfoliate with the skin to achieve the effect of removing melasma. However, melasma is a dermal spot with deeper pigmentation, so it is difficult for retinoic acid cream to reach the lesion. The color of melasma will become lighter after peeling off the epidermis, but it will recur easily. Retinoic acid cream can be used to treat epidermal spots, such as freckles or sun spots, as well as acne, pimple marks, and flat warts. Some patients may experience redness or peeling of the skin after using retinoic acid cream, which usually recovers on its own after stopping the medication. The cause of melasma is not completely clear at present, and it is mainly related to heredity, sun exposure, late night and other factors. Melasma can be treated with hydroquinone cream or azelaic acid cream externally, as well as dye pulse laser, Q-switched ruby laser and other physical treatments. Normally, it is necessary to pay attention to going to bed early and getting up early, avoiding sunshine and reducing anger or tension. It is suggested that patients with chloasma should go to the dermatology department of hospitals for consultation in time, and standardize the treatment under the guidance of doctors, and the use of drugs should follow the doctor’s instructions.