Prolonged high-dose use of linaclotide is resistant and may produce adverse reactions, taking linaclotide needs to be directed by a doctor. Linaclotide can be used to treat constipated irritable bowel syndrome in adults by speeding up the rate of bowel movements, increasing bowel movements and improving bowel pain. If linaclotide is used for a long period of time and in high doses, the rate of bowel movement is weakened after stopping the use of linaclotide, and constipation and other discomforts are likely to occur. Short-term or occasional use of linaclotide is essentially unlikely to result in drug resistance. Adverse reactions such as viral gastroenteritis, metabolic disorders, malnutrition, dizziness, diarrhea, abdominal distension, and flatulence may occur with the administration of linaclotide. The drug is contraindicated in persons who are hypersensitive to linaclotide or any excipients, in children under 6 years of age, and in patients with known or suspected mechanical gastrointestinal obstruction. Linaclotide should be taken under medical supervision and should not be abused.