Minimally invasive Ar-He knife surgery refers to minimally invasive intervention in tumor lesions through super-guided needles under the guidance of ultrasound or CT imaging equipment, freezing the tumor to extremely low temperature (180 degrees to minus 150 degrees) in an instant, and then rapidly re-tempering to normal temperature (about 30 degrees) after complete freezing, causing tumor cells to rupture and die through the principle of alternating hot and cold. It can kill the lesion and remove the tumor. It is a kind of minimally invasive tumor treatment technology emerging at the end of 20th century. The characteristics of minimally invasive Ar-He knife surgery for mid- to late-stage lung cancer are as follows: 1. The cancer cells in the lung within the treatment area die completely. It is comparable to palliative surgery. 2. Pure physical green therapy, no harm to lung tissues other than lung tumor and other body tissues, no toxic side effects, and high quality of life for patients. 3.Minimally invasive without incision, painless treatment and fast recovery after surgery. 4.It can rapidly stop pain and remove pain, reduce cancer symptoms and improve the quality of life. 5.It can be repeatedly treated for many times, which is also applicable to patients with recurrent, metastatic and multiple lung cancers. 6.Fast recovery after surgery, short hospitalization time and low overall cost. 7. Argon helium ultracold knife minimally invasive surgery is precisely controlled, with minimal damage to surrounding normal tissues, and is also applicable to patients with special or huge tumors; 8. No serious lung treatment complications caused by treatment injury, and low treatment risk.