Wake up after a sleep eyeballs full of blood clots may be due to severe coughing, violent rubbing the eyes and other physiological factors, may also be due to acute conjunctivitis caused by the frequent occurrence of this situation also need to exclude the possibility of blood diseases. 1. Physiological factors: usually patients with a strong cough and violent rubbing of the eyes, often lead to patients with subconjunctival hemorrhage, which will appear to sleep and wake up eyeballs full of blood clots phenomenon, is a normal physiological phenomenon, generally self-absorption. 2. Acute conjunctivitis: usually due to a variety of microbial infections, mostly adenovirus infection, herpes simplex infection, staphylococcus aureus infection. The course of the disease is shorter, the onset of more acute, patients often appear conjunctival congestion and edema, bright red, and severe cases can also appear point flake subconjunctival hemorrhage, can also be manifested as a sleep and wake up the eyeballs are full of blood clots. 3. Blood diseases: repeated frequent occurrence of this bleeding, it is recommended to consult a doctor in time to rule out the possibility of blood diseases. For example, if there is thrombocytopenic purpura or other diseases, it is necessary to refer to the hematology department for treatment. The patient woke up after a nap with blood clots in the eyeballs, accompanied by other discomfort, it is recommended to consult a doctor for examination, to clarify the cause of the disease, and then follow the doctor’s instructions to carry out systematic treatment.