Positive EBV nuclear antigen IgG suggests possible Burkitt lymphoma and nasopharyngeal carcinoma, which should be treated with appropriate drugs or surgery. 1. Burkitt lymphoma: composed of small anaplastic cells with consistent morphology, it is a serious aggressive non-Hodgkin’s lymphoma. Stages Ⅰ and Ⅱ advocate the palliative principle of observation and waiting, and if the disease progresses, it can be treated by single use of nitrogen mustard phenylbutyrate or cyclophosphamide, and stages Ⅲ and Ⅶ are mainly treated by CHOP regimen. 2. Nasopharyngeal cancer: PF program without metastasis is preferred, i.e. cisplatin and 5-fluorouracil; cisplatin is preferred for radiotherapy in the same period; nitolizumab is chosen for targeted therapy; cetuximab has better near-term efficacy for advanced localized nasopharyngeal cancer. When EBV nuclear antigen IgG is positive, one should consult a doctor in time to clarify the nature and choose the appropriate treatment under the guidance of specialized doctors.