Persistent low fever and sweating at night for two months may be due to tuberculosis and hyperthyroidism. It can be relieved by using anti-tuberculosis drugs and anti-thyroid drugs. If tuberculosis is caused by infection with tubercle bacilli, symptoms such as low afternoon fever, malaise and night sweats may occur, and when the disease is long and the disease is not fully controlled, persistent low fever and sweating at night for two months may occur. At this time, it should be treated promptly with anti-tuberculosis drugs. If there is hyperthyroidism, the patient’s body thyroid hormone increase, resulting in hypermetabolism, may appear at night persistent low fever sweating for two months, but also often have easy to agitation, irritability and insomnia and other symptoms. At this time, anti-thyroid drugs such as methimazole and carbimazole can be used for treatment. If there are other reasons for persistent low fever and sweating at night for two months, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or standardized treatment.