Methylprednisolone 2 tablets a day is the normal dosage of the drug, the possible adverse drug reactions include drug allergic reaction, Cushing’s syndrome, infection and so on. Methylprednisolone is one of the glucocorticoid drugs, which can be used to treat rheumatic diseases, skin diseases, allergic diseases, eye diseases, respiratory diseases, etc. The common specifications of the drug are 4mg/tablet and 16mg/tablet, and depending on the patient’s specific disease and condition, the initial dosage of the drug can be adjusted between 4mg/day and 48mg/day. The most common adverse drug reactions to 2 tablets of methylprednisolone per day are infections, peritonitis, Cushing’s-like syndrome, and allergic reactions. It is contraindicated in people who are allergic to the drug, systemic fungal infections. Pay attention to the control of infections during the use of the drug, monitor adverse reactions, and gradually reduce the dose before discontinuing the drug after long-term use. Methylprednisolone should be used under the guidance of a physician, it is recommended that patients go to the relevant departments of regular hospitals for detailed consultation.