Large coffee spots can generally be removed by laser treatment, cryotherapy, skin resurfacing, and for those who are suspected to have neurofibromatosis, they need to undergo surgery as early as possible. 1. Laser treatment: The high intensity laser produced by laser treatment instrument can directly penetrate the skin and act on the pigment in the skin, prompting the pigment to dissipate, thus achieving the effect of removing coffee spots. 2. Cryotherapy: Using the extremely low temperature of liquid nitrogen, local tissues are frozen and necrotic in a very short time, including the pigment cells in the epidermis, and the effect of removing coffee spots can be achieved after the pigment cells are necrotic. 3. Skin resurfacing: remove the outermost layer of the skin by skin resurfacing, so as to lighten the coffee spots. 4. Surgery: For coffee spots caused by neurofibromatosis, surgery is the only way to treat the primary disease. Since there are some individual differences in the treatment effect, you must ask your doctor to evaluate the specific situation and make a suitable treatment plan according to your own situation.