Stubborn constipation can be treated with oral medication or anal medication. Oral medication choice of osmotic laxatives, including such as lactulose or magnesium sulfate and other related drugs, but also can choose to enhance the intestinal power of oral drugs, including mosapride, domperidone and so on. Anal medication in general can be anally put into the corkscrew or the compound coriander acid ester preparation, suitable for dry stool or stool mosaic in the anus of the patient. Frequent constipation or many days without stool and accompanied by severe abdominal pain, do not take medication without authorization, must go to the hospital for examination to see whether there is intestinal obstruction or intestinal perforation and other related diseases before treatment, so as not to delay the condition.